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These metabolites suppress NLRP3 inflammasome activation via TGR5, thereby reducing systemic inflammation

MOTS c supports mitochondrial function and cellular energy regulation which may improve reproductive health

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This is because weight gain is common even after bariatric surgery and can lead to the recurrence of obesity-related complications

A study conducted on DOCA salt hypertensive mice has shown decreased levels of the limiting enzyme of the sepiapterin conversion to BH4, sepiapterin reductase (SPR), in aortic endothelial cells compared with the endothelium-denuded aortic ones

Clinical Considerations for Patients Using Both Substances Patients currently prescribed tirzepatide who use or are considering using cannabis should discuss this openly with their GP or diabetes specialist