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Blocking MR receptors and interfering with glucocorticoids stimulation of glutamate activity counteracted stress-induced suppression of the histone acetyltransferase p300 mRNA levels in the hippocampus, showing a link between glucocorticoids and epigenetic programming of the glutamatergic system [20]

11.7 Practical Takeaway Framework During GLP-1 therapy: Prioritise protein intake Increase micronutrient density per calorie Monitor symptoms Test selectively when risk factors are present Avoid automatic or excessive supplementation Reassess after significant weight milestones Weight loss should be metabolically effective and nutritionally sufficient