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It works by mimicking ghrelin , the hunger hormone, and binding to the growth hormone secretagogue receptor (GHS-R1a) without increasing cortisol or prolactin levels like older peptides such as GHRP-6 or GHRP-2

Contraindicated for use in clients with liver and kidney insufficiency and those who are breastfeeding or pregnant

But production declines with age, stress, illness, toxin exposure, and poor nutrition

Health Syst

Within UK research peptide markets, GHK-Cu is often discussed alongside regenerative signalling peptides such as BPC-157 and metabolic compounds including NAD+

However, indirect mechanismsincluding reduced caloric intake from appetite suppression, gastrointestinal symptoms affecting nutrition, and metabolic changes from weight lossmay contribute to feelings of fatigue