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MALE FERTILITY AND SPERMATOGENESIS Hypogonadotropic Hypogonadism: Steroidogenesis Restoration Serum testosterone: increase from 200 ng/dL above baseline Primary failure: no response (Leydig cell damage) Secondary failure: present response but low baseline Applications: Differentiation between primary and secondary hypogonadism Pre-pubertal Leydig cell reserve evaluation Treatment response prediction 5

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10.1016/j.neuroscience.2005.02.030 Neuroscience 73 ShintokuR.TakigawaY.YamadaK.KubotaC.YoshimotoY.TakeuchiT.et al (2017)