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Each compound is always drawn separately and injected separately, even when both are administered in the same session

This phenomenon, known as early worsening, typically occurs within the first three to six months of treatment and affects approximately 10-20% of patients with pre-existing retinal disease

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Author Contributions Conceived and designed the experiments: DL HL X

Pharmacokinetic Uncertainties Smaller doses may behave differently than expected: Absorption variability: Smaller volumes may have different kinetics Injection site effects: Multiple sites per week increase variability Threshold effects: Minimum concentration needed for efficacy unknown Receptor occupancy: May need sustained levels for full effect 4

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